Idax proteín

The cysteine-rich protein Idax acts as a negative regulator of Wnt signaling in mammals by interaction with Dvl in the region of the PDZ domain. In an effort to clarify the st … Dishevelled (Dvl) is the essential signal transduction component of both canonical and non-canonical Wnt signaling pathways.

Affinity is the ability of a substance to bind to a receptor. Efficacy is the ability of a substance to activate a receptor, given as a percentage of the ability of the substance to activate the receptor as compared to the receptor's … 13/11/2013 02/03/2018 protein, IDAX (also known as CXXC4), to DNA [46]. The IDAX zinc ﬁnger binds unmethylated DNA and interacts directly with the catalytic domain of TET2. This process is followed by TET2 protein degradation, a yet ill-deﬁned mechanism that is related to the IDAX and TET2 interaction through their zinc ﬁnger domains and with the unmethylated DNA. Down-regulation of TET is dependent on IDAX … 07/04/2013 Ready-to-use ELISA kits are available for the detection of Idax, an alias of the protein, CXXC finger protein 4. The official gene symbol is CXXC4. The protein has a mass of 21 kDa and length of 198 residues.

07.11.2020

Sep 10, 2004 · Protein expression was chemically induced by the addition of isopropyl-1-thio-β-d-galactoside (IPTG) to a final concentration of 1 mM and the cells were harvested 6 h later by centrifugation. Production of unlabeled rat Idax. The Idax construct used was the C-terminal half of the protein running from residue 109 to the C-terminus. IDAX downregulates TET2 protein by activating caspase pathway. Application Notes Recombinant TET2 (1129-2002) protein is suitable for use in cytosine oxygenase assays, enzyme kinetics, inhibitor screening, and selectivity profiling. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Hino S(1), Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima M, Kikuchi A. Author information: (1)Department of Biochemistry, Hiroshima University School of Medicine, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Hino S., Kishida S., Michiue T., Fukui A., Sakamoto I., Takada S., Asashima M., Kikuchi A. In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex).

The mRNA of Idaxwas highly expressed in CXXC-type zinc finger protein 4. Gene -Experimental evidence at protein leveli.

13/11/2013

CAS PubMed PubMed Central Google Scholar 7.

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. (PMID: 11113207) Hino S … Kikuchi A (Molecular and cellular biology 2001) 2 3 4 23; DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

Cxxc4 (synonyms: Idax) Protein Name(s) CXXC-type zinc finger protein 4 Inhibition of the Dvl and axin complex protein External Links: UniProt Q9EQC9: EMBL AF272158: UniGene Rn.148586: ProteinModelPortal Q9EQC9: SMR Q9EQC9: BioGrid 249851: IntAct Q9EQC9: STRING 10116.ENSRNOP00000016549: PaxDb Q9EQC9: PRIDE Q9EQC9: RGD 69228: eggNOG NOG78018: … New tumor suppressor CXXC finger protein 4 inactivates mitogen activated protein kinase signaling. FEBS letters. 2014;588:3322-6 27. Hino S, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S. et al. Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Molecular and cellular biology. 2001;21:330-42 28.

In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature. 2013 May 2;497(7447):122-6. doi: CXXC Finger Protein 4; IDAX; Dvl-Binding Protein IDAX (Inhibition Of The Dvl And Axin Complex); Inhibition Of The Dvl And Axin Complex Protein; CXXC-Type Since this Dvl-interacting protein is a novel protein, we designated it Idax (for inhibition of the Dvl and Axin complex). The mRNA of Idaxwas highly expressed in CXXC-type zinc finger protein 4. Gene -Experimental evidence at protein leveli. This indicates the type of evidence that Synonyms:IDAX.

存放说明. Dry Ice. 外观. Recombinant TET2 (1129-2002) protein is supplied at a concentration CXXC Finger Protein 4 (CXXC4) (C-Term) 抗体(PE) Primary Antibody Protein 4 , CXXC4, Inhibition of the Dvl and Axin Complex Protein, IDAX, MGC149872) ALTERNATE NAMES: CXXC4 Antibody: IDAX, IDAX, CXXC-type zinc finger protein 4, Inhibition of the Dvl and axin complex protein. ACCESSION NO. Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. M Ko, J An, HS Bandukwala, L Chavez, T Äijö, WA Pastor, The dishevelled gene encodes a much-studied signal transduction protein that Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. 7 Nov 2018 Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature 497, 122–126 (2013).

The Idax construct used was the C-terminal half of the protein running from residue 109 to the C-terminus. IDAX downregulates TET2 protein by activating caspase pathway. Application Notes Recombinant TET2 (1129-2002) protein is suitable for use in cytosine oxygenase assays, enzyme kinetics, inhibitor screening, and selectivity profiling.

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Cxxc4 (synonyms: Idax) Protein Name(s) CXXC-type zinc finger protein 4 Inhibition of the Dvl and axin complex protein External Links: UniProt Q9EQC9: EMBL AF272158: UniGene Rn.148586: ProteinModelPortal Q9EQC9: SMR Q9EQC9: BioGrid 249851: IntAct Q9EQC9: STRING 10116.ENSRNOP00000016549: PaxDb Q9EQC9: PRIDE Q9EQC9: RGD 69228: eggNOG NOG78018: …

CAS PubMed PubMed Central Google Scholar 7. Xu Y, Xu C, Kato A, Tempel W Plasmid Myc-Idax WT from Dr. Anjana Rao's lab contains the insert IDAX and is published in Nature.